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Tim E Cawston Selected Research

type 2 alpha 1 Collagenopathy

3/2012Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.
12/2010Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.
5/2009A novel paradigm for dendritic cells as effectors of cartilage destruction.
1/2003Cytokine synergy, collagenases and cartilage collagen breakdown.

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Tim E Cawston Research Topics

Disease

4Osteoarthritis
03/2012 - 10/2006
4type 2 alpha 1 Collagenopathy
03/2012 - 01/2003
4Arthritis (Polyarthritis)
11/2010 - 01/2005
2Joint Diseases (Joint Disease)
12/2010 - 05/2008
2Rheumatoid Arthritis
01/2007 - 06/2003
2Inflammation (Inflammations)
12/2006 - 06/2003
1Obesity
03/2012
1Knee Osteoarthritis
03/2012
1Bronchiolitis
12/2006
1Bronchiolitis Obliterans Syndrome
12/2006
1Airway Remodeling
12/2006
1Bone Resorption
10/2006
1Rheumatic Diseases (Rheumatism)
06/2005
1Pathologic Processes
06/2005
1Cardiovascular Diseases (Cardiovascular Disease)
06/2005
1Lung Diseases (Lung Disease)
06/2005
1Necrosis
01/2005

Drug/Important Bio-Agent (IBA)

5Matrix Metalloproteinases (MMPs)IBA
12/2010 - 01/2003
4Interleukin-1 (Interleukin 1)IBA
03/2012 - 06/2003
4CytokinesIBA
12/2010 - 01/2003
2EnzymesIBA
12/2010 - 01/2007
2Serine Proteases (Serine Protease)IBA
07/2010 - 10/2006
2Collagenases (Collagenase)FDA Link
05/2008 - 01/2003
2Matrix Metalloproteinase InhibitorsIBA
10/2006 - 06/2005
1Conditioned Culture MediaIBA
03/2012
1LeptinIBA
03/2012
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
12/2010
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
12/2010
1LithiumIBA
11/2010
1matriptaseIBA
07/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2009
1Biomarkers (Surrogate Marker)IBA
09/2007
1CilomilastIBA
12/2006
1Cysteine Proteases (Cysteine Protease)IBA
10/2006
1Doxycycline (Periostat)FDA LinkGeneric
10/2006
1Oncostatin MIBA
01/2005
1Peptide Hydrolases (Proteases)FDA Link
01/2003

Therapy/Procedure

2Therapeutics
11/2010 - 10/2006
1Lung Transplantation
12/2006